Volume 15, Issue 58, 2026 (April – June)
Research Article
Synthesis, spectral characterization, DNA cleavage, and antimicrobial activity of transition metal (II) complexes of pyranochromene derivatives
Disha Tilala, Kamlesh Gurjar, Naveen Kumar Sharma, Denish Karia
Keywords: Metal (II) complexes, Calf Thymus DNA, antimicrobial, in vitro.
DOI:10.37273/chesci.cs132057031
Full Text – PDF
Abstract
New ligands LIII = 3-acetyl-4-hydroxy-7-methylpyrano
[3,2-c]chromene-2,5-dione, LIX = 4-hydroxy-7-methyl-3-(3-oxobutanoyl)pyrano[3,2-c]chromene-2,5-dione and their metal(II) complexes M[LIII(H2O)]2 and M[LIX(H2O)]2 were synthesized using transition metals iron, cobalt, nickel and characterized by UV, FT-IR, mass spectra, 1H NMR and elemental analysis,. The conductivity of metal complexes was determined. In the presence of H2O2 at 37°C, complexes can efficiently cleave Calf Thymus DNA. Ligands and their metal (II) complexes also show good in vitro antimicrobial activity. Copper complexes of both ligands have highest DNA cleavage ability and also shows maximum zone of inhibition indicating higher antimicrobial activities.
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