Volume 14, Issue 54, 2025 (April – June)
Research Article
Evaluation of anti-urolithiatic potential of Pongamia pinnata Leaves on Kidney Stone
Kesavan Devarayan, Seethaladevi Chellappan, Sabariswaran Kandasamy, Ayyannan Ganesan, Asrar Ahmed Abdullah
Keywords: Pongamia pinnata, anti-urolithiatic, kidney stone, nucleation inhibition, aggregation inhibition, calcium oxalate, antibacterial activity, urolithiasis.
DOI:10.37273/chesci.cs012056061
Abstract
The anti-urolithiatic potential of Pongamia pinnata leaf extract, obtained through ethanol extraction, and its correlation with the phytochemical composition is described in this study. Phytochemicals such as resins, flavonoids, carbohydrates, saponins, alkaloids, proteins, and gums are present in the plant extract. Nucleation and aggregation studies revealed the efficacy of the extract against calcium oxalate crystal formation. Additionally, the extract demonstrated antibacterial activity against Propionibacterium acnes and Pseudomonas aeruginosa, enhancing its potential for managing urolithiasis-related infections. Spectral analyses, including UV-Visible and FT-IR spectroscopy, confirmed the presence of phytochemicals having potential for their anti-inflammatory, antioxidant, and diuretic activities. These results suggest that Pongamia pinnata holds promise as a natural remedy for preventing and managing kidney stones, and a promising candidate for further investigation for its clinical applications.
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